We provide testing of Active Pharmaceutical Substances (
Method development and validation for
· Small molecules to Large molecules (peptides, proteins).
· Single component and multi-components
· Different modes of HPLC like Normal-phase, Reversed Phase (RP-HPLC), Ion-Pair,
Ion- Exchange (Cation-Exchange and Anion Exchange), Size Exclusion (
· Difficult to develop compounds by HPLC like (No / Poor UV Compounds, In-organic Ions, etc)
· HPLC’s equipped with UV-Vis., PDA, Refractive Index (RI) and Fluorescence Detection Capabilities
and Fraction collectors.
· Thin Layer Chromatography.
· USP Dissolution Apparatus (USP Apparatus
1 and 2) and Modified In-Vitro Release Apparatus for Different New Dosage forms and Devices containing pharmaceutically active substances.
· Disintegration Tester
· UV-Visible Spectrophotometer (Single Beam and Double Beam)
· Stability Chambers
at 2°C to 8°C, -20°C, 25°C/60%RH, 30°C/65%RH, 40°C/75%RH and chambers to meet Custom conditions needed by clients.
· Differential Scanning Calorimeter (DSC)
· Scanning Electron Microscope (
· Malvern Particle
Size Analyzer.
· Osmometer
Ø Assay Method Development and validation services for following as per
v Support in formulation development
v Release testing of Active Pharmaceutical Substances (
v Stability testing programs.
Ø Impurities Method Development and validation services for following as per ICH/FDA/USP guidelines:
v Active Pharmaceutical Substances (
v Pre-formulation / Drug-Drug and Drug-Excipients compatibility studies.
v Finished drug products
v Devices containing
pharmaceutically active substances and
v Stability testing programs.
Ø Dissolution (In- Vitro Drug
Release) Method Development and validation for following as per
v Intrinsic Dissolution / Solubility of Active
Pharmaceutical Substances (
v Finished drug products including Modified Release Dosage forms.
v Devices containing
pharmaceutically active substances and
v Stability testing programs.
Ø Cleaning Validation method
to determine, if residual cleaning agents and/or active ingredients are present in equipment, coupons or a swab/wipe including swab
recovery and Material recovery form swab after controlled spike.
Ø Stability testing for Active
Pharmaceutical Substances (
v Refrigerated (2°C to 8°C),
v Freezer (-20°C),
v Controlled
Room Temperature (25°C/60%RH),
v Intermediate Condition (30°C/65%RH),
v Accelerated Condition (40°C/75%RH) and
v Any other Custom conditions
needed by clients.
Ø Powder Morphology Testing using Scanning Electron Microscopy (
Ø Polymorph / Excipients Interaction testing using Differential Scanning
Calorimeter (DSC).
Ø Osmolarity of solutions using Osmometer.
Ø Laboratory Enzyme assays for measuring enzymatic activity for the study of enzyme kinetics and enzyme inhibition using UV-Vis Spectrophotometer.