Ø       Solubility Screening and Enhancement:

v Solubility screening of drugs, effect of pH, ionic strength, and formulation composition on solubility.

v Solubility enhancement by use of cosolvents, solubilizing agents, inclusion complexing agents, hydrophilic agents, and lipid vehicles.

v Solubility enhancement by solid dispersions, and spray drying.

v Dissolution rate enhancement by nanomilling.

Ø       Permeation Studies:

v Permeation of drugs across synthetic membranes, biologic tissues (porcine buccal, sublingual, intestinal, and cadaver skin), and cell lines (CaCo2 - human colon cancer cell line).

v Enhancement of permeation by manupulation of vehicle pH, and surfactants.

Ø       Moisture Uptake / Hygroscopicity:

v Moisture content by Karl-Fisher titration, and screening of powders and granules for moisture uptake.

Ø       Thermal Analysis:

v Evaluation of drug-drug or drug-excipient interactions based on changes in polymorphs and/or melting point.

Ø       Surface Morphology and Particle Size Analysis:

v Analysis of surface morphology of micronized particles by scanning electron micrography. Size and zeta potential of micron and submicron particles or emulsion globules by light scattering technique.

Ø       Granules Characterization:

v Physical characterization of granules for bulk density, tapped density, compressibility, flow nature, moisture content, moisture uptake / hygroscopicity, sieve analysis, and compaction.

Ø       Compatibility Studies:

v Evaluation of drug-drug or drug-excipient interactions based on thermal and chromatographic analysis.

Ø       Physical Stability of Disperse Systems:

v Evaluation of physical stability of emulsions and suspensions by microscopic and sedimentation methods.

Ø       Bioadhesion Testing:

v Screening of bioadhesive properties of polymers with synthetic or biologic tissues; Enhancement of bioadhesion and wetting properties of high molecular weight polymers; In vitro screening of gastroretention time.

Ø       Nano-Sizing:

v Size reduction of particles by milling and evaluation of physical stability of dispersions.